Darbepoetin alfa (Aranesp)
Dosage form:
Pre-filled syringes: 10 mcg (25 mcg/mL); 15 mcg (40 mcg/mL); 20 mcg (40 mcg/mL); 30 mcg (100 mcg/mL); 40 mcg (100 mcg/mL); 50 mcg (100 mcg/mL); 60 mcg (200 mcg/mL); 80 mcg (200 mcg/mL); 100 mcg (200 mcg/mL); 150 mcg (500 mcg/mL); 300 mcg (500 mcg/mL); 500 mcg (500 mcg/mL)
Pharmacological group:
Hematopoietic stimulant
Therapeutic use:
Treatment of anemia associated with chronic kidney disease and others
Dosage:
Dogs:
0.25–0.5 mcg/kg subcutaneously weekly until hematocrit normalizes, then gradually increase injection interval
Cats:
0.25–0.5 mcg/kg subcutaneously weekly until hematocrit normalizes, then gradually increase injection interval
Denaverinum Hydrochloride (Sensiblex)
Dosage form:
Solution 40 mg/mL in vials of various sizes
Pharmacological group:
Antispasmodic
Therapeutic use:
Relaxes smooth muscle of the cervix and increases elasticity of the birth canal. Used to regulate parturition in cows and dogs.
Dosage:
Dogs:
0.5–1.5 mL per animal (20–60 mg denaverinum hydrochloride)
Deslorelin (Suprelorin)
Dosage form:
Implant containing 4.7 mg
Pharmacological group:
GnRH (gonadotropin-releasing hormone) agonist implant
Therapeutic use:
Chemical castration; treatment of adrenal hyperplasia in ferrets
Dosage:
Dogs:
1 implant per animal
Cats:
Off-label: 1 implant per animal; in males effective approximately 20 months, in females approximately 24 months.
Ferrets:
1 implant per animal; effect approximately 2 years
Dexamethasone (Azium, Dexasone, Decadron) / Dexafort (long-acting)
Dosage form:
Tablets 0.5 mg. Injectable solution: 4 mg/mL (human), 2 mg/mL (veterinary 0.2%), 4 mg/mL (veterinary 0.4%). Dexafort suspension: 2.67 mg dexamethasone phenylpropionate + 1.32 mg dexamethasone sodium phosphate per mL.
Pharmacological group:
Glucocorticosteroids
Therapeutic use:
Anti-inflammatory, antiallergic, and gluconeogenic effects. Used when glucocorticosteroids are indicated. Stronger effect than prednisolone.
Dosage:
Dogs:
1) Anti-inflammatory: 0.01–0.16 mg/kg intramuscularly, subcutaneously, or intravenously once every 24 hours.
2) Anaphylaxis: 0.5 mg/kg intravenously.
3) Immunosuppression: 0.3–0.64 mg/kg intramuscularly, subcutaneously, or orally once every 24 hours.
2) Anaphylaxis: 0.5 mg/kg intravenously.
3) Immunosuppression: 0.3–0.64 mg/kg intramuscularly, subcutaneously, or orally once every 24 hours.
Cats:
1) Anti-inflammatory: 0.01–0.16 mg/kg intramuscularly, subcutaneously, or intravenously once every 24 hours.
2) Anaphylaxis: 0.5 mg/kg intravenously.
3) Immunosuppression: 0.3–0.64 mg/kg intramuscularly, subcutaneously, or orally once every 24 hours.
2) Anaphylaxis: 0.5 mg/kg intravenously.
3) Immunosuppression: 0.3–0.64 mg/kg intramuscularly, subcutaneously, or orally once every 24 hours.
Dexmedetomidine (Dexdomitor, Sileo)
Dosage form:
Injectable solution 0.1 mg/mL and 0.5 mg/mL
Pharmacological group:
Alpha-2 adrenomimetic
Therapeutic use:
Sedation and premedication
Dosage:
Dogs:
3–5 mcg/kg intravenously, intramuscularly, or subcutaneously
Cats:
3–5 mcg/kg intravenously, intramuscularly, or subcutaneously
Diazepam (Valium, Diastat)
Dosage form:
Injectable solution 5 mg/mL; tablets 5 mg, 10 mg; rectal suppositories 5 mg, 10 mg
Pharmacological group:
Benzodiazepine tranquilizer
Therapeutic use:
Anticonvulsant, anxiolytic, muscle relaxant. For rapid control of severe seizures.
Dosage:
Dogs:
1) Anxiolytic: 0.5–2 mg/kg orally.
2) Sedation and premedication: 0.2–0.5 mg/kg intravenously or intramuscularly.
3) Skeletal muscle relaxation: 2–10 mg per dog orally every 8–12 hours.
4) Emergency seizure control: 0.5–1 mg/kg intravenously or rectally.
2) Sedation and premedication: 0.2–0.5 mg/kg intravenously or intramuscularly.
3) Skeletal muscle relaxation: 2–10 mg per dog orally every 8–12 hours.
4) Emergency seizure control: 0.5–1 mg/kg intravenously or rectally.
Cats:
1) Anxiolytic: 0.2–0.4 mg/kg orally every 8 hours.
2) Appetite stimulant: 0.5–1 mg/kg intravenously as a single dose.
3) Emergency seizure control: 0.5–1 mg/kg intravenously or rectally.
2) Appetite stimulant: 0.5–1 mg/kg intravenously as a single dose.
3) Emergency seizure control: 0.5–1 mg/kg intravenously or rectally.
Diclofenac ophthalmic drops (Voltaren Ophthalmic)
Dosage form:
Ophthalmic drops: 1 mg/mL
Pharmacological group:
NSAID
Therapeutic use:
To reduce inflammation and provide analgesia
Dosage:
Dogs:
1 drop in affected eye(s) every 6–12 hours
Cats:
1 drop in affected eye(s) every 6–12 hours
Diphenhydramine Hydrochloride (Benadryl)
Dosage form:
Injectable solution 10 mg/mL in 1 mL ampoules
Pharmacological group:
Antihistamine
Therapeutic use:
H1 histamine receptor blockade; mild sedative; mild antipruritic
Dosage:
Dogs:
Mild sedation: 2–4 mg/kg every 6–8 hours. Pruritus control: 1–2 mg/kg every 8–12 hours. Orally, subcutaneously, or intramuscularly.
Cats:
2–4 mg/kg every 6–8 hours orally, subcutaneously, or intramuscularly
Birds:
2–4 mg/kg orally every 12 hours
Dopamine (Intropin)
Dosage form:
Concentrate for infusion solution 40 mg/mL
Pharmacological group:
Dopaminergic agent
Therapeutic use:
Improvement of hemodynamic status. Used in shock, acute heart failure, and to maintain blood pressure during anesthesia.
Dosage:
Dogs:
2–10 mcg/kg/min intravenously as a constant rate infusion
Cats:
1–5 mcg/kg/min intravenously as a constant rate infusion
Doxycycline Hydrochloride / Doxycycline Monohydrate (Vibramycin, Doryx, Monodox)
Dosage form:
Capsules 100 mg; tablets 100 mg
Pharmacological group:
Tetracycline-class antibiotic
Therapeutic use:
Broad-spectrum antibacterial activity; active against Rickettsiae, Mycoplasma, Chlamydia
Dosage:
Dogs:
10 mg/kg orally once every 24 hours, or 5 mg/kg orally every 12 hours, with food
Cats:
10 mg/kg orally once every 24 hours, or 5 mg/kg orally every 12 hours, with food
Drotaverine Hydrochloride (No-Spa, Buscopan)
Dosage form:
Tablets 20 mg, 40 mg, 80 mg; injectable solution 20 mg/mL
Pharmacological group:
Antispasmodic
Therapeutic use:
As an antispasmodic agent
Dosage:
Dogs:
1–2 mg/kg intramuscularly once every 24 hours
Cats:
1–2 mg/kg intramuscularly once every 24 hours